Reactome | p-T9-TIFA [cytosol]

p-T9-TIFA [cytosol]

Stable Identifier

R-HSA-9645512

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TRAF-interacting protein with FHA domain-containing protein A, TIFA_HUMAN

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Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-1 family signaling (Homo sapiens)
      - Interleukin-1 signaling (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Homo sapiens)
        
        p-T9-TIFA [cytosol] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Alpha-protein kinase 1 signaling pathway (Homo sapiens)
    - ALPK1 phosphorylates TIFA (Homo sapiens)
      - ALPK1:ADP-heptose:p-T9-TIFA dimer [cytosol] (Homo sapiens)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Homo sapiens)
        
        p-T9-TIFA [cytosol] (Homo sapiens)
    - ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Homo sapiens)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Homo sapiens)
        
        p-T9-TIFA [cytosol] (Homo sapiens)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Homo sapiens)
        
        p-T9-TIFA [cytosol] (Homo sapiens)
    - ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Homo sapiens)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Homo sapiens)
        
        p-T9-TIFA [cytosol] (Homo sapiens)
      - ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Homo sapiens)
        
        p-T9-TIFA [cytosol] (Homo sapiens)
    - Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation (Homo sapiens)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Homo sapiens)
        
        p-T9-TIFA [cytosol] (Homo sapiens)
    - Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Homo sapiens)
      - ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Homo sapiens)
        
        p-T9-TIFA [cytosol] (Homo sapiens)
      - ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Homo sapiens)
        
        p-T9-TIFA [cytosol] (Homo sapiens)
    - Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Homo sapiens)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Homo sapiens)
        
        p-T9-TIFA [cytosol] (Homo sapiens)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Homo sapiens)
        
        p-T9-TIFA [cytosol] (Homo sapiens)
    - TIFA oligomerization (Homo sapiens)
      - ALPK1:ADP-heptose:p-T9-TIFA dimer [cytosol] (Homo sapiens)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Homo sapiens)
        
        p-T9-TIFA [cytosol] (Homo sapiens)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Homo sapiens)
        
        p-T9-TIFA [cytosol] (Homo sapiens)
    - TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Homo sapiens)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Homo sapiens)
        
        p-T9-TIFA [cytosol] (Homo sapiens)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Homo sapiens)
        
        p-T9-TIFA [cytosol] (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Homo sapiens)
        
        p-T9-TIFA [cytosol] (Homo sapiens)
    - Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
      - Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Homo sapiens)
        
        p-T9-TIFA [cytosol] (Homo sapiens)
      - Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Homo sapiens)
        
        p-T9-TIFA [cytosol] (Homo sapiens)
    - Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
      - TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Homo sapiens)
        
        p-T9-TIFA [cytosol] (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Homo sapiens)
        
        p-T9-TIFA [cytosol] (Homo sapiens)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Homo sapiens)
        
        p-T9-TIFA [cytosol] (Homo sapiens)
    - Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Homo sapiens)
        
        p-T9-TIFA [cytosol] (Homo sapiens)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Homo sapiens)
        
        p-T9-TIFA [cytosol] (Homo sapiens)
    - Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Homo sapiens)
        
        p-T9-TIFA [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96CG3 TIFA

Gene Names

TIFA, T2BP

Chain

chain:1-184

Reference Genes

BioGPS Gene:92610 TIFA

COSMIC (genes):TIFA TIFA

CTD Gene:92610 TIFA

dbSNP Gene:92610 TIFA

ENSEMBL:ENSG00000145365 TIFA

ENSEMBL_homo_sapiens_GENE:ENSG00000145365.12 TIFA

HGNC:19075 TIFA

KEGG Gene (Homo sapiens):92610 TIFA

Monarch:92610 TIFA

NCBI Gene:92610 TIFA

OMIM:609028 TIFA

UCSC:Q96CG3 TIFA

Reference Transcript

RefSeq:NM_052864.2 TIFA

Other Identifiers

11720681_at

11720682_at

16979050

226117_PM_at

226117_at

235971_PM_at

235971_at

238858_PM_at

238858_at

2782222

2782224

2782226

2782228

2782229

2782231

2782232

2782233

2782234

2782235

2782236

2782237

2782239

2782240

2782241

64119_at

70543_at

76951_at

8102362

92610

A_23_P352619

A_24_P350686

GE517341

GE767989

GO:0002376

GO:0002753

GO:0005515

GO:0005737

GO:0005829

GO:0007249

GO:0023052

GO:0043123

GO:0045087

GO:0050896

GO:0051260

GO:0065003

GO:0098542

HMNXSV003033964

Hs.126490.0.A1_3p_at

Hs.310640.0.A1_3p_at

Hs.3985.0.A1_3p_at

ILMN_1686454

PH_hs_0020480

PH_hs_0029723

TC04001476.hg

Participates

as a component of

p-T9-TIFA:p-T9-TIFA [cytosol] (Homo sapiens)

Other forms of this molecule

TIFA [cytosol]

Inferred To

phospho-tifa [cytosol] (Xenopus tropicalis)

phospho-Tifa [cytosol] (Mus musculus)

phospho-Tifa [cytosol] (Rattus norvegicus)

phospho-TIFA [cytosol] (Bos taurus)

phospho-TIFA [cytosol] (Canis familiaris)

phospho-TIFA [cytosol] (Gallus gallus)

phospho-TIFA [cytosol] (Sus scrofa)

Modified Residues

Name

O-phospho-L-threonine at 9

Coordinate

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_443096.1

OpenTargets

ENSG00000145365

HPA

ENSG00000145365-TIFA

GeneCards

Q96CG3

Ensembl

ENSP00000516322, ENST00000500655, ENSG00000145365, ENSP00000424231, ENST00000610220, ENSP00000354911, ENST00000361717

PRO

Q96CG3

Pharos - Targets

Q96CG3

Orphanet

24981

PDB

4YM4, 4ZGI, 6A33, 5ZUJ

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.844	13
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.795	8
UniProt:Q9UBU9 NXF1	2	NXF1 [cytosol] (R-HSA-156481) NXF1 [nucleoplasm] (R-HSA-111690)	0.718	6
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [endosome membrane] (R-HSA-450272) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955)	0.702	6
UniProt:O14641 DVL2	5	pp-DVL2 [cytosol] (R-HSA-3772398) p-DVL2 [cytosol] (R-HSA-201706) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444) DVL2 [cytosol] (R-HSA-201694) ub-DVL2 [cytosol] (R-HSA-4652689)	0.621	3
UniProt:O60443 GSDME	18	GSDME(1-270) G199E [cytosol] (R-HSA-9710427) GSDME(1-270) R48I [cytosol] (R-HSA-9710474) GSDME(1-270) I137T [cytosol] (R-HSA-9710473) GSDME W46* [cytosol] (R-HSA-9711042) GSDME(1-270) D18V [cytosol] (R-HSA-9710466) GSDME(1-270) D14Y [cytosol] (R-HSA-9710450) GSDME(1-270) P212L [cytosol] (R-HSA-9710487) GSDME(1-270) W44C [cytosol] (R-HSA-9710470) GSDME(1-270) I217N [cytosol] (R-HSA-9710437) GSDME E210* [cytosol] (R-HSA-9710420) GSDME(1-270) [cytosol] (R-HSA-9647689) GSDME [cytosol] (R-HSA-9647620) GSDME (271-496) [cytosol] (R-HSA-9647615) GSDME(1-270) E177V [cytosol] (R-HSA-9710403) GSDME(1-270) T196M [cytosol] (R-HSA-9710429) GSDME(1-270) G17D [cytosol] (R-HSA-9710478) GSDME(1-270) E134A [cytosol] (R-HSA-9710410) GSDME(1-270) N24D [cytosol] (R-HSA-9710404)	0.556	3
UniProt:P54646 PRKAA2	4	PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [cytosol] (R-HSA-200417) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.556	3
UniProt:Q99757 TXN2	2	TXN2 [mitochondrial matrix] (R-HSA-3323048) 2xHC-TXN2 [mitochondrial matrix] (R-HSA-3323059)	0.556	3
UniProt:P70196 Traf6	9	Traf6 [cytosol] (R-MMU-6783233) Traf6 [cytosol] (R-MMU-6782845) Traf6 [cytosol] (R-MMU-933459) Traf6 [endosome membrane] (R-MMU-450272) Traf6 [endosome membrane] (R-MMU-450227) Traf6 [plasma membrane] (R-MMU-936955) Traf6 [plasma membrane] (R-MMU-936980) Traf6 [cytosol] (R-MMU-2685681) Traf6 [cytosol] (R-MMU-166366)	0.499	4
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.488	2

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