16098514 |
Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1
Proud, CG,
Blenis, J,
Tee, AR
|
FEBS Lett. |
2005 |
29053970 |
mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient
Chen, WW,
Sabatini, DM,
Danai, LV,
Abu-Remaileh, M,
Wyant, GA,
Vander Heiden, MG,
Freinkman, E,
Wolfson, RL
|
Cell |
2017 |
25561175 |
SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1
Bigenzahn, JW,
Huber, KV,
Indiveri, C,
Bennett, KL,
Rebsamen, M,
Superti-Furga, G,
Kandasamy, RK,
Rudashevskaya, EL,
Snijder, B,
Galluccio, M,
Huber, LA,
Heinz, LX,
de Araújo, ME,
Pochini, L,
Fauster, A,
Filipek, PA,
Bruckner, M,
Scorzoni, S,
Kraft, C,
Stasyk, T
|
Nature |
2015 |
30844724 |
Recent advances in understanding of amino acid signaling to mTORC1 activation
Wang, XX,
Zhuang, Y,
Yin, Y,
He, J,
He, S
|
Front Biosci (Landmark Ed) |
2019 |
26378229 |
Amino Acid Availability Modulates Vacuolar H+-ATPase Assembly
Forgac, M,
Stransky, LA
|
J. Biol. Chem. |
2015 |
29123071 |
SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway
Sabatini, DM,
Scaria, SM,
Gu, X,
Saxton, RA,
Gygi, SP,
Liu, GY,
Harper, JW,
Condon, KJ,
Krawczyk, PA,
Orozco, JM
|
Science |
2017 |
25567906 |
Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1
Sabatini, DM,
Wang, T,
Zoncu, R,
Jones, TD,
Comb, W,
Park, J,
Straub, C,
Wang, S,
Shen, K,
Tsun, ZY,
Bar-Peled, L,
Plovanich, ME,
Chantranupong, L,
Sabatini, BL,
Kim, C,
Yuan, ED,
Wyant, GA,
Wolfson, RL
|
Science |
2015 |
25567907 |
Metabolism. Differential regulation of mTORC1 by leucine and glutamine
Park, HW,
Russell, RC,
Guan, KL,
Yu, FX,
Tagliabracci, VS,
Kim, YC,
Plouffe, SW,
Jewell, JL
|
Science |
2015 |
30181260 |
Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms
Sabatini, DM,
Shen, K
|
Proc. Natl. Acad. Sci. U.S.A. |
2018 |
20381137 |
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
Sabatini, DM,
Zoncu, R,
Sancak, Y,
Bar-Peled, L,
Nada, S,
Markhard, AL
|
Cell |
2010 |
27487210 |
Mechanism of arginine sensing by CASTOR1 upstream of mTORC1
Sabatini, DM,
Schwartz, TU,
Saxton, RA,
Chantranupong, L,
Knockenhauer, KE
|
Nature |
2016 |
28066558 |
Structural mechanism for the arginine sensing and regulation of CASTOR1 in the mTORC1 signaling pathway
Yang, C,
Wang, Q,
Gai, Z,
Deng, W,
Wang, L,
Wu, G
|
Cell Discov |
2016 |
25457612 |
Sestrins inhibit mTORC1 kinase activation through the GATOR complex
Budanov, AV,
Nourbakhsh, A,
Ding, B,
Guan, KL,
Kim, YC,
Akopiants, K,
Wang, W,
Karin, M,
Parmigiani, A
|
Cell Rep |
2014 |
25263562 |
The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1
Sabatini, DM,
Scaria, SM,
Spooner, E,
Saxton, RA,
Gygi, SP,
Bar-Peled, L,
Chantranupong, L,
Isasa, M,
Orozco, JM,
Wolfson, RL
|
Cell Rep |
2014 |
27648300 |
Structural insight into the arginine-binding specificity of CASTOR1 in amino acid-dependent mTORC1 signaling
Ding, J,
Wang, R,
Zhang, T,
Xia, J
|
Cell Discov |
2016 |
26972053 |
The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway
Sabatini, DM,
Wang, T,
Scaria, SM,
Saxton, RA,
Gygi, SP,
Gygi, MP,
Chantranupong, L,
Harper, JW,
Wyant, GA,
Shen, K
|
Cell |
2016 |
29236692 |
Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40
Yang, A,
Yang, HJ,
Jiang, X,
Li, B,
Pavletich, NP,
Yang, H,
Dhar, A,
Miller, M
|
Nature |
2017 |
17470430 |
The Rheb switch 2 segment is critical for signaling to target of rapamycin complex 1
Busch, S,
Lin, Y,
Long, X,
Avruch, J,
Ortiz-Vega, S
|
J. Biol. Chem. |
2007 |
26449471 |
Sestrin2 is a leucine sensor for the mTORC1 pathway
Sabatini, DM,
Scaria, SM,
Saxton, RA,
Chantranupong, L,
Cantor, JR,
Shen, K,
Wolfson, RL
|
Science |
2016 |
15854902 |
Rheb binds and regulates the mTOR kinase
Yonezawa, K,
Ortiz-Vega, S,
Avruch, J,
Lin, Y,
Long, X
|
Curr Biol |
2005 |
26586190 |
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
Sabatini, DM,
Schwartz, TU,
Wang, T,
Pacold, ME,
Saxton, RA,
Chantranupong, L,
Knockenhauer, KE,
Wolfson, RL
|
Science |
2016 |
28199306 |
KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1
Sabatini, DM,
Petri, S,
Condon, KJ,
Shen, K,
Orozco, JM,
Scaria, SM,
Gu, X,
Frankel, WN,
Chantranupong, L,
Kedir, J,
Abu-Remaileh, M,
Wyant, GA,
Wolfson, RL
|
Nature |
2017 |
18497260 |
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
Thoreen, CC,
Shaul, YD,
Sabatini, DM,
Sancak, Y,
Bar-Peled, L,
Lindquist, RA,
Peterson, TR
|
Science |
2008 |
15878852 |
Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency
Lin, Y,
Long, X,
Avruch, J,
Ortiz-Vega, S
|
J. Biol. Chem. |
2005 |
30061680 |
A nutrient-induced affinity switch controls mTORC1 activation by its Rag GTPase-Ragulator lysosomal scaffold
Rappold, R,
Zoncu, R,
Cho, KF,
Kim, DJ,
Hurley, JH,
Moldavski, O,
Tofaute, M,
Lawrence, RE,
Thrun, A
|
Nat. Cell Biol. |
2018 |
29056322 |
Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability
Sabatini, DM,
Choe, A,
Shen, K
|
Mol. Cell |
2017 |
30602761 |
mTOR as a central hub of nutrient signalling and cell growth
Guan, KL,
Kim, J
|
Nat. Cell Biol. |
2019 |
28686218 |
Lysosomal Regulation of mTORC1 by Amino Acids in Mammalian Cells
Inoki, K,
Yao, Y,
Jones, E
|
Biomolecules |
2017 |
18604198 |
Regulation of TORC1 by Rag GTPases in nutrient response
Guan, KL,
Neufeld, TP,
Kim, E,
Goraksha-Hicks, P,
Li, L
|
Nat. Cell Biol. |
2008 |
29311260 |
mTOR signaling in stem and progenitor cells
Frank, AR,
Meng, D,
Jewell, JL
|
Development |
2018 |
22053050 |
mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase
Sabatini, DM,
Sancak, Y,
Zoncu, R,
Bar-Peled, L,
Efeyan, A,
Wang, S
|
Science |
2011 |
28768171 |
The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway
Sabatini, DM,
Wolfson, RL
|
Cell Metab. |
2017 |
29078414 |
Twenty-five years of mTOR: Uncovering the link from nutrients to growth
Sabatini, DM
|
Proc. Natl. Acad. Sci. U.S.A. |
2017 |
24529380 |
Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2
Demetriades, C,
Teleman, AA,
Doumpas, N
|
Cell |
2014 |