Blockage of phagosome acidification

Stable Identifier
R-HSA-9636467
Type
Pathway
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Blockage of phagosome acidification
Click the image above or here to open this pathway in the Pathway Browser
Acidification of the phagosome occurs by insertion of ATPases into the phagosomal membrane in preparation for fusion with lysosomes. The pH of phagosomes containing Mtb never drops below 6.5 due to Mtb interfering with several acidification mechanisms (Queval et al. 2017).
Literature References
PubMed ID Title Journal Year
28954234 Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling

Queval, CJ, Deboosère, N, Tomavo, S, Yeramian, E, Debrie, AS, Song, OR, Bongiovanni, A, Gouveia, JC, Park, SJ, Brodin, P, Carralot, JP, Deloison, G, Brosch, R, Iantomasi, R, Saliou, JM, Delorme, V, Jouny, S, Yoshimura, A

Cell Rep 2017
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
suppression by symbiont of host innate immune response (0052170)
Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Stephan, R  (2019-02-06)
Reviewed
Wilkinson, RJ  (2019-10-23)
Deffur, A  (2019-10-23)
Created
Koile, I  (2019-02-13)
Cite Us!