Inhibition of nitric oxide production

Stable Identifier
R-HSA-9636249
Type
Pathway
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
ReviewStatus
5/5
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Inhibition of nitric oxide production
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Phagocytes produce nitric oxide to damage interned bacteria before fusion of the phagosome with lysosomes. While Mtb has several pathways to neutralize NO it also attempts to block the host enzymes used for NO production (Fang 2004, Bhat 2017).
Literature References
PubMed ID Title Journal Year
15378046 Antimicrobial reactive oxygen and nitrogen species: concepts and controversies

Fang, FC

Nat Rev Microbiol 2004
28071726 The PPE2 protein of Mycobacterium tuberculosis translocates to host nucleus and inhibits nitric oxide production

Ghosh, S, Mukhopadhyay, S, Kotturu, SK, Bhat, KH, Srivastava, S

Sci Rep 2017
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Event Information
Go Biological Process
suppression by symbiont of host innate immune response (0052170)
Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Stephan, R  (2019-02-06)
Reviewed
Wilkinson, RJ  (2019-10-23)
Deffur, A  (2019-10-23)
Created
Koile, I  (2019-02-12)
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