Reactome | LINC01139 promotes phosphorylation of HIF1A by LRRK2

LINC01139 promotes phosphorylation of HIF1A by LRRK2

Stable Identifier

R-HSA-9634702

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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LINC01139 promotes phosphorylation of HIF1A by LRRK2

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LRRK2 serine/threonine kinase, activated via long non-coding RNA LINC01139 (LINK-A) mediated recruitment to phosphorylated GPNMB (bound to HBEGF-activated EGFR), phosphorylates hypoxia inducible factor 1 alpha (HIF1A) at serine residue S797. LRRK2-mediated phosphorylation of HIF1A at S797 promotes association of HIF1A with EP300 (p300) transcriptional co-activator and inhibits association of HIF1A with a transactivation inhibitor HIF1AN (FIH) (Lin et al. 2016).

Literature References

PubMed ID	Title	Journal	Year
26751287	The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer Marks, JR, Yang, L, Zhou, Y, Ma, G, Wang, S, Xing, Z, Liang, H, Lin, A, Hu, Z, Han, L, Hu, Q, Zhou, Y, Lin, C, Wang, C, Park, PK, Li, C, Zhou, J, Liang, K, Hung, MC, Zhang, Y, Wei, Y, Hawke, DH	Nat. Cell Biol.	2016