Estrogen-dependent nuclear events downstream of ESR-membrane signaling

Stable Identifier
R-HSA-9634638
Type
Pathway
Species
Homo sapiens
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Although membrane-localized estrogen receptors stimulate rapid, transcription-independent responses such as calcium mobilization and alterations to the fibronectin matrix to affect cell migration, among others, the pathways activated by rapid signaling may also ultimately affect nuclear events. Activation of MAPK and PI3K/AKT pathways downstream of membrane-localized ESR1 contributes to estrogen-responsive changes in cellular proliferation and survival in part through changes in gene expression (reviewed in Levin et al, 2005; Lange et al, 2007; Le Romancer et al, 2011).

Literature References
PubMed ID Title Journal Year
15705661 Integration of the extranuclear and nuclear actions of estrogen

Levin, ER

Mol. Endocrinol. 2005
17037979 Integration of rapid signaling events with steroid hormone receptor action in breast and prostate cancer

Lange, CA, Gioeli, D, Hammes, SR, Marker, PC

Annu. Rev. Physiol. 2007
21680538 Cracking the estrogen receptor's posttranslational code in breast tumors

Le Romancer, M, Poulard, C, Cohen, P, Sentis, S, Renoir, JM, Corbo, L

Endocr. Rev. 2011
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