PTK2 (also known as FAK) is co-immunoprecipitated with methylated ESR1 and PI3K after stimulation with estrogen. This interaction depends on ESR1 methylation and on SRC activity, as it is abrogated in the presence of SRC inhibitors or upon PRMT1 depletion (Le Romancer et al, 2008). Phosphorylation of PTK2 appears to be dynamic, as it is lost within 15 minutes of estrogen stimulation, promoting disassembly of the complex. Interaction with PTK2 may contribute to estrogen-stimulated cell motility.
Le Romancer, M,