HSPA8:substrate binds late endosomal phospholipids

Stable Identifier
R-HSA-9631068
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Microautophagy (MI) can target KFERQ motif containing protein substrates to endosomal degradation. Upon binding with HSPA8, substrates are transported from the cytosol to late endosomes. Here, HSPA8 binds with the phospholipids on the late endosomal membrane. This interaction facilitates the vesicle-mediated transport of HSPA8:substrate complex into the late endosomes for degradation (Sahu R et al. 2011). Experiments confirming this interaction were performed in mouse cells.
Literature References
PubMed ID Title Journal Year
21238931 Microautophagy of cytosolic proteins by late endosomes

Cuervo, AM, Potolicchio, I, Cannizzo, ES, Follenzi, A, Scharf, B, Kaushik, S, Santambrogio, L, Sahu, R, Nieves, E, Clement, CC

Dev. Cell 2011
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