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SIRT1 deacetylates FOXO1
Stable Identifier
R-HSA-9626962
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
Regulation of FOXO transcriptional activity by acetylation (Homo sapiens)
SIRT1 deacetylates FOXO1 (Homo sapiens)
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A histone deacetylase SIRT1 deacetylates FOXO1. Deacetylation increases FOXO1-mediated upregulation of SOD2 and CDKN1B (Diatoku et al. 2004). SIRT-dependent deacetylation leads to retention of FOXO1 in the nucleus (Frescas et al. 2005).
Participants
Input
Ac-K245,K248,K265-FOXO1 [nucleoplasm]
(Homo sapiens)
x 3
NAD+ [nucleoplasm]
Output
x 3
2'-O-acetyl-ADP-ribose [nucleoplasm]
FOXO1 [nucleoplasm]
(Homo sapiens)
x 3
NAM [nucleoplasm]
Participates
as an event of
Regulation of FOXO transcriptional activity by acetylation (Homo sapiens)
Catalyst Activity
protein lysine deacetylase activity of SIRT1 [nucleoplasm]
Physical Entity
SIRT1 [nucleoplasm]
(Homo sapiens)
Activity
protein lysine deacetylase activity (GO:0033558)
Inferred From
Sirt1 deacetylates Foxo1 (Mus musculus)
Authored
Orlic-Milacic, M (2018-10-31)
Reviewed
Bertaggia, E (2018-10-26)
Created
Orlic-Milacic, M (2018-10-30)
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