FOXO3,FOXO4 bind STK11 gene promoter

Stable Identifier
R-HSA-9625375
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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FOXO3,FOXO4 bind STK11 gene promoter
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FOXO3 and FOXO4 bind to forkhead box elements in the promoter region of the STK11 (LKB1) gene, encoding Serine/threonine-protein kinase STK11 (also known as Liver kinase B1). The promoter of the STK11 gene also possesses binding sites for transcription factors NF-Y and SP1. It is unclear if FOXO3 and FOXO4 cooperate with NF-Y and SP1 in the induction of STK11 transcription (Lutzner et al. 2012).
Literature References
PubMed ID Title Journal Year
22412893 Gene expression of the tumour suppressor LKB1 is mediated by Sp1, NF-Y and FOXO transcription factors

Lützner, N, Rösl, F, De-Castro Arce, J

PLoS ONE 2012
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Authored
Orlic-Milacic, M  (2018-10-23)
Reviewed
Donlon, T  (2018-10-23)
Created
Orlic-Milacic, M  (2018-10-19)
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