AKT-phosphorylated FOXO3 translocates to cytosol

Stable Identifier
R-HSA-9624527
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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AKT-mediated phosphorylation of FOXO3 downstream of estrogen stimulation promotes its inactivation and translocation to the cytosol, interfering with its pro-apoptotic transcription factor activity (Richards et al, 2002; Brunet et al, 1999; reviewed in Levin, 2005; Burgering, 2008).
Literature References
PubMed ID Title Journal Year
10102273 Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

Hu, LS, Bonni, A, Brunet, A, Blenis, J, Zigmond, MJ, Anderson, MJ, Lin, MZ, Greenberg, ME, Juo, P, Arden, KC

Cell 1999
18391968 A brief introduction to FOXOlogy

Burgering, BM

Oncogene 2008
11875118 Expression of FKHR, FKHRL1, and AFX genes in the rodent ovary: evidence for regulation by IGF-I, estrogen, and the gonadotropins

Lo, YH, Falender, AE, Richards, JS, Sharma, SC

Mol. Endocrinol. 2002
15705661 Integration of the extranuclear and nuclear actions of estrogen

Levin, ER

Mol. Endocrinol. 2005
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