AKT phosphorylates FOXO3 downstream of ESR1 and EGFR

Stable Identifier
R-HSA-9624526
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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AKT phosphorylation of the pro-apoptotic Forkhead transcription factor FOXO3 and other Foxo family members occurs downstream of E2 stimulation (Richards et al, 2002; reviewed in Levin, 2005). AKT-mediated phosphorylation promotes nuclear export, resulting in a decrease in expression of apoptosis-promoting FOXO3-target genes (Brunet et al, 1999; reviewed in Burgering, 2008).

Literature References
PubMed ID Title Journal Year
18391968 A brief introduction to FOXOlogy

Burgering, BM

Oncogene 2008
10102273 Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

Brunet, A, Bonni, A, Zigmond, MJ, Lin, MZ, Juo, P, Hu, LS, Anderson, MJ, Arden, KC, Blenis, J, Greenberg, ME

Cell 1999
11875118 Expression of FKHR, FKHRL1, and AFX genes in the rodent ovary: evidence for regulation by IGF-I, estrogen, and the gonadotropins

Richards, JS, Sharma, SC, Falender, AE, Lo, YH

Mol. Endocrinol. 2002
15705661 Integration of the extranuclear and nuclear actions of estrogen

Levin, ER

Mol. Endocrinol. 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T,p-S-AKT [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created