BCL gene expression downstream of ESR1

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R-HSA-9623999
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Reaction [omitted]
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Homo sapiens
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BCL2 mRNA and protein levels increase in response to E2 stimulation in a PKA-dependent manner (Grimaldi et al, 2002; Yune et al, 2008). Levels of phosphorylated CREB1 also increase with estrogen stimulation, however direct binding of phosphorylated CREB to the BCL2 promoter has not been demonstrated. Estrogen-dependent BCL2 expression is also dependent on Sp1 (Dong et al, 1999; Yune et al, 2008; reviewed in Ladikou and Kassi, 2017).

Literature References
PubMed ID Title Journal Year
10542244 Mechanisms of transcriptional activation of bcl-2 gene expression by 17beta-estradiol in breast cancer cells

Dong, L, Wang, W, Wang, F, Stoner, M, Reed, JC, Harigai, M, Samudio, I, Kladde, MP, Vyhlidal, C, Safe, S

J. Biol. Chem. 1999
18785877 Estrogen-induced Bcl-2 expression after spinal cord injury is mediated through phosphoinositide-3-kinase/Akt-dependent CREB activation

Yune, TY, Park, HG, Lee, JY, Oh, TH

J. Neurotrauma 2008
12070310 Estrogen alters thresholds for B cell apoptosis and activation

Grimaldi, CM, Cleary, J, Dagtas, AS, Moussai, D, Diamond, B

J. Clin. Invest. 2002
27557932 The emerging role of estrogen in B cell malignancies

Ladikou, EE, Kassi, E

Leuk. Lymphoma 2017
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