ESR1-dependent CCND1 expression

Stable Identifier
R-HSA-9623355
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ESR1-dependent CCND1 expression
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Expression of CCND1, the gene encoding cyclin D1, is stimulated by treatment of cells with E2. Expression is dependent on ESR1-mediated signaling through the PKA and AKT pathways, and consistent with this, levels of phosphorylated CREB1 increase upon treatment with E2. The CCND1 promoter has a CRE element that is bound by phosphorylated CREB1 upon E2 treatment as assessed by electrophoretic mobility shift assay (Park et al, 2001; Felty et al, 2005).
Literature References
PubMed ID Title Journal Year
11243864 Reduction in cyclin D1/Cdk4/retinoblastoma protein signaling by CRE-decoy oligonucleotide

Cho-Chung, YS, Lim, SO, Lee, MS, Ryu, CK, Kim, I, Park, YG, Park, S

Biochem. Biophys. Res. Commun. 2001
15897899 Estrogen-induced G1/S transition of G0-arrested estrogen-dependent breast cancer cells is regulated by mitochondrial oxidant signaling

Singh, KP, Felty, Q, Roy, D

Oncogene 2005
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
CCND1 gene:p-S133 CREB1 dimer [nucleoplasm] (Homo sapiens)
Active Unit
p-S133-CREB1 [nucleoplasm]
Authored
Rothfels, K  (2018-12-15)
Reviewed
Levin, ER  (2019-02-20)
Created
Rothfels, K  (2018-10-04)
Cite Us!