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FOXO1 binds PPARGC1A
Stable Identifier
R-HSA-9623240
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes (Homo sapiens)
FOXO1 binds PPARGC1A (Homo sapiens)
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Based on experiments in a mouse model system, FOXO1 forms a complex with the transcriptional co-activator PPARGC1A (PGC-1alpha). The interaction between FOXO1 and PPARGC1A is disrupted by AKT-mediated phosphorylation of FOXO1 (Puigserver et al. 2003).
Participants
Input
FOXO1 [nucleoplasm]
(Homo sapiens)
PPARGC1A [nucleoplasm]
(Homo sapiens)
Output
FOXO1:PPARGC1A [nucleoplasm]
(Homo sapiens)
Participates
as an event of
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes (Homo sapiens)
Inferred From
Foxo1 binds Ppargc1a (Mus musculus)
Authored
Orlic-Milacic, M (2018-10-11)
Reviewed
Bertaggia, E (2018-10-26)
Donlon, T (2018-10-17)
Created
Orlic-Milacic, M (2018-10-03)
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