KAT2B,EP300 acetylate FOXO3 under oxidative stress

Stable Identifier
R-HSA-9620515
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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KAT2B,EP300 acetylate FOXO3 under oxidative stress
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KAT2B (PCAF) and possibly EP300 (p300) acetylate FOXO3 under conditions of oxidative stress (Brunet et al. 2004).
Literature References
PubMed ID Title Journal Year
14976264 Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

Sinclair, DA, Jedrychowski, MP, Greenberg, ME, Brunet, A, Alt, FW, Gygi, SP, Hu, LS, Ross, SE, Lin, Y, Cohen, HY, Sweeney, LB, Chua, KF, Sturgill, JF, Mostoslavsky, R, Tran, H, Cheng, HL, Greer, PL

Science 2004
Participants
Input
Output
Participates
as an event of
Catalyst Activity

peptide-lysine-N-acetyltransferase activity of KAT2B,(EP300) [nucleoplasm]

Physical Entity
KAT2B,(EP300) [nucleoplasm] (Homo sapiens)
Activity
peptide-lysine-N-acetyltransferase activity (GO:0061733)
This event is regulated
Positively by
Regulator
ROS [nucleoplasm]
Orthologous Events
KAT2B,EP300 acetylate FOXO3 under oxidative stress (Bos taurus)
KAT2B,EP300 acetylate FOXO3 under oxidative stress (Caenorhabditis elegans)
KAT2B,EP300 acetylate FOXO3 under oxidative stress (Canis familiaris)
KAT2B,EP300 acetylate FOXO3 under oxidative stress (Danio rerio)
KAT2B,EP300 acetylate FOXO3 under oxidative stress (Drosophila melanogaster)
KAT2B,EP300 acetylate FOXO3 under oxidative stress (Gallus gallus)
KAT2B,EP300 acetylate FOXO3 under oxidative stress (Mus musculus)
KAT2B,EP300 acetylate FOXO3 under oxidative stress (Rattus norvegicus)
KAT2B,EP300 acetylate FOXO3 under oxidative stress (Sus scrofa)
KAT2B,EP300 acetylate FOXO3 under oxidative stress (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2018-10-11)
Reviewed
Bertaggia, E  (2018-10-26)
Donlon, T  (2018-10-17)
Created
Orlic-Milacic, M  (2018-09-25)
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