FLT3 Signaling

Stable Identifier
R-HSA-9607240
Type
Pathway
Species
Homo sapiens
Compartment
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Feline McDonough Sarcoma-like tyrosine kinase (FLT3) (also known as FLK2 (fetal liver tyrosine kinase 2), STK-1 (stem cell tyrosine kinase 1) or CD135) is a member of the class III receptor tyrosine kinase family involved in the differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Upon FLT3 ligand (FL) binding, the receptor forms dimers and is phosphorylated. Consequently, adapter and signaling molecules bind with the active receptor and trigger the activation of various pathways downstream including PI3K/Akt and MAPK cascades (Grafone T et al. 2012).

Literature References
PubMed ID Title Journal Year
25992210 An overview on the role of FLT3-tyrosine kinase receptor in acute myeloid leukemia: biology and treatment

Grafone, T, Palmisano, M, Nicci, C, Storti, S

Oncol Rev 2012
Participants
Participant Of
Event Information
Orthologous Events
Reviewed
Created