Phosphorylated SPRY2 is ubiquitinated by CBL

Stable Identifier
R-HSA-934604
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Phosphorylated SPRY2 is ubiquitinated by CBL
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In humans, the phosphorylated adaptor protein Sprouty2 is ubiquitinated by the E3 ubiquitin ligase CBL, marking it for degradation by the 26S proteasome.
Literature References
PubMed ID Title Journal Year
12593796 hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl

Hall, AB, Jura, N, Gong, D, DaSilva, J, Bar-Sagi, D, Jang, YJ

Curr Biol 2003
12593795 Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops

Litvak, V, Lev, S, Zwang, Y, Yarden, Y, Medvedovsky, H, Rubin, C

Curr Biol 2003
Participants
Input
Output
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as an event of
Catalyst Activity

ubiquitin protein ligase activity of Y55/Y227-pSPRY2:CBL [plasma membrane]

Physical Entity
Y55/Y227-pSPRY2:CBL [plasma membrane] (Homo sapiens)
Activity
ubiquitin protein ligase activity (GO:0061630)
Orthologous Events
Phosphorylated SPRY2 is ubiquitinated by CBL (Bos taurus)
Phosphorylated SPRY2 is ubiquitinated by CBL (Canis familiaris)
Phosphorylated SPRY2 is ubiquitinated by CBL (Danio rerio)
Phosphorylated SPRY2 is ubiquitinated by CBL (Drosophila melanogaster)
Phosphorylated SPRY2 is ubiquitinated by CBL (Gallus gallus)
Phosphorylated SPRY2 is ubiquitinated by CBL (Mus musculus)
Phosphorylated SPRY2 is ubiquitinated by CBL (Rattus norvegicus)
Phosphorylated SPRY2 is ubiquitinated by CBL (Sus scrofa)
Authored
Williams, MG  (2010-08-17)
Reviewed
Gotoh, N  (2011-08-26)
Created
Williams, MG  (2010-08-17)
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