TFRC dimer binds 2xholoTF

Stable Identifier
R-HSA-917987
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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TFRC dimer binds 2xholoTF
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Transferrin receptor 1 (TFRC) molecules can be found on the outside of any cell. Transferrin (TF), loaded with iron (holoTF), transports two ferric iron ions through the blood and two holoTFs bind to a TFRC dimer, which mediates cellular uptake of holoTF in a non-iron dependent manner (West et al. 2001).
Literature References
PubMed ID Title Journal Year
11800564 Mutational analysis of the transferrin receptor reveals overlapping HFE and transferrin binding sites

Snow, PM, Pierce, JR, Bennett, MJ, Bjorkman, PJ, Weiner, LP, Nangiana, JS, Herr, AB, Giannetti, AM, West AP, Jr

J Mol Biol 2001
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Orthologous Events
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TFRC dimer binds 2xholoTF (Sus scrofa)
Authored
Stephan, R  (2010-07-11)
Reviewed
D'Eustachio, P  (2010-11-05)
Created
Jassal, B  (2010-07-30)
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