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Transferrin endocytosis and recycling
Stable Identifier
R-HSA-917977
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Transport of small molecules (Homo sapiens)
Iron uptake and transport (Homo sapiens)
Transferrin endocytosis and recycling (Homo sapiens)
General
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Endocytosis of iron loaded transferrin/receptor complex leads, after acidification of the endosome, to the separation of iron and its diffusion out of the vesicle. The endosome is not fused with a lysosome but recycles its content back to the cell surface where soon transferrin dissociates from its receptor (Dautry-Varsat, 1986).
Literature References
PubMed ID
Title
Journal
Year
2874839
Receptor-mediated endocytosis: the intracellular journey of transferrin and its receptor
Dautry-Varsat, A
Biochimie
1986
Participants
Events
HFE binds TFRC dimer
(Homo sapiens)
TFRC dimer binds 2xholoTF
(Homo sapiens)
TFR2 dimer binds 2xholoTF
(Homo sapiens)
holoTF:TFRC dimer translocates from plasma membrane to endosome membrane
(Homo sapiens)
ATP6AP1 binds V-ATPase
(Homo sapiens)
Acidification of Tf:TfR1 containing endosome
(Homo sapiens)
Fe3+ dissociates from holoTF:TFRC dimer
(Homo sapiens)
STEAP3,STEAP4 reduce Fe3+ to Fe2+
(Homo sapiens)
MCOLN1 transports Fe2+ from endosome lumen to cytosol
(Homo sapiens)
apoTF:TFRC dimer translocates from endosome membrane to plasma membrane
(Homo sapiens)
apo-Transferrin dissociates from the receptor complex
(Homo sapiens)
Participates
as an event of
Iron uptake and transport (Homo sapiens)
Event Information
Go Biological Process
transferrin transport (0033572)
Orthologous Events
Transferrin endocytosis and recycling (Bos taurus)
Transferrin endocytosis and recycling (Caenorhabditis elegans)
Transferrin endocytosis and recycling (Canis familiaris)
Transferrin endocytosis and recycling (Danio rerio)
Transferrin endocytosis and recycling (Dictyostelium discoideum)
Transferrin endocytosis and recycling (Drosophila melanogaster)
Transferrin endocytosis and recycling (Gallus gallus)
Transferrin endocytosis and recycling (Mus musculus)
Transferrin endocytosis and recycling (Plasmodium falciparum)
Transferrin endocytosis and recycling (Rattus norvegicus)
Transferrin endocytosis and recycling (Saccharomyces cerevisiae)
Transferrin endocytosis and recycling (Schizosaccharomyces pombe)
Transferrin endocytosis and recycling (Sus scrofa)
Transferrin endocytosis and recycling (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000498
Authored
Stephan, R (2010-07-11)
Reviewed
D'Eustachio, P (2010-11-05)
Created
Jassal, B (2010-07-30)
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