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HC-ABCG2 [plasma membrane]
Stable Identifier
R-HSA-917929
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
ABCG2
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
NFE2L2 regulating MDR associated enzymes (Homo sapiens)
NFE2L2 dependent ABCG2 expression (Homo sapiens)
HC-ABCG2 [plasma membrane] (Homo sapiens)
Developmental Biology (Homo sapiens)
Developmental Cell Lineages (Homo sapiens)
Differentiation of keratinocytes in interfollicular epidermis in mammalian skin (Homo sapiens)
Keratinocyte stem cell differentiates into transit amplifying cell in the basal layer of interfollicular epidermis (Homo sapiens)
keratinocyte stem cell of skin epidermis basal layer (Homo sapiens)
HC-ABCG2 [plasma membrane] (Homo sapiens)
Drug ADME (Homo sapiens)
Abacavir ADME (Homo sapiens)
Abacavir transmembrane transport (Homo sapiens)
abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate (Homo sapiens)
ABCG2 tetramer [plasma membrane] (Homo sapiens)
HC-ABCG2 [plasma membrane] (Homo sapiens)
Paracetamol ADME (Homo sapiens)
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Homo sapiens)
ABCC2, ABCG2 tetramer [plasma membrane] (Homo sapiens)
ABCG2 tetramer [plasma membrane] (Homo sapiens)
HC-ABCG2 [plasma membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Sphingolipid metabolism (Homo sapiens)
Sphingolipid de novo biosynthesis (Homo sapiens)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Homo sapiens)
ABCC1,ABCG2 [plasma membrane] (Homo sapiens)
HC-ABCG2 [plasma membrane] (Homo sapiens)
Metabolism of porphyrins (Homo sapiens)
Heme biosynthesis (Homo sapiens)
ABCG2 tetramer transports heme from cytosol to extracellular region (Homo sapiens)
ABCG2 tetramer [plasma membrane] (Homo sapiens)
HC-ABCG2 [plasma membrane] (Homo sapiens)
Heme degradation (Homo sapiens)
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Homo sapiens)
ABCG2 tetramer [plasma membrane] (Homo sapiens)
HC-ABCG2 [plasma membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Iron uptake and transport (Homo sapiens)
ABCG2 tetramer transports heme from cytosol to extracellular region (Homo sapiens)
ABCG2 tetramer [plasma membrane] (Homo sapiens)
HC-ABCG2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UNQ0 ABCG2
Gene Names
ABCG2, ABCP, BCRP, BCRP1, MXR
Chain
chain:1-655
Reference Genes
BioGPS Gene:9429 ABCG2
COSMIC (genes):ABCG2 ABCG2
CTD Gene:9429 ABCG2
dbSNP Gene:9429 ABCG2
ENSEMBL:ENSG00000118777 ABCG2
ENSEMBL_homo_sapiens_GENE:ENSG00000118777.12 ABCG2
HGNC:74 ABCG2
KEGG Gene (Homo sapiens):9429 ABCG2
Monarch:9429 ABCG2
NCBI Gene:9429 ABCG2
OMIM:603756 ABCG2
UCSC:Q9UNQ0 ABCG2
Reference Transcript
RefSeq:XM_005263355.3 ABCG2
RefSeq:NM_004827.2 ABCG2
RefSeq:XM_011532420.2 ABCG2
RefSeq:NM_001257386.1 ABCG2
Other Identifiers
11724537_a_at
11724538_a_at
16977868
209735_PM_at
209735_at
2777284
2777285
2777286
2777287
2777288
2777289
2777290
2777291
2777292
2777293
2777295
2777296
2777297
2777298
2777299
2777300
2777301
2777303
2777305
2777306
2777308
2777309
2777310
2777312
2777313
33733_at
8101675
9429
A_23_P18713
A_33_P3361067
GE575063
GE81445
GO:0000166
GO:0003013
GO:0003014
GO:0003824
GO:0005215
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005739
GO:0005886
GO:0006869
GO:0008514
GO:0008559
GO:0015143
GO:0015225
GO:0015562
GO:0015711
GO:0015747
GO:0015878
GO:0016020
GO:0016324
GO:0016787
GO:0016887
GO:0031526
GO:0031966
GO:0032217
GO:0032218
GO:0042626
GO:0042802
GO:0042803
GO:0042910
GO:0043226
GO:0045121
GO:0046415
GO:0046983
GO:0055085
GO:0070633
GO:0097744
GO:0098591
GO:0098754
GO:0140115
GO:0140359
GO:0140657
GO:0150104
GO:1990748
GO:1990962
HMNXSV003049042
ILMN_1789641
PH_hs_0011514
TC04001370.hg
TC04002625.hg
g12414050_3p_at
Participates
as a protein marker of
keratinocyte stem cell of skin epidermis basal layer (Homo sapiens)
as an output of
NFE2L2 dependent ABCG2 expression (Homo sapiens)
as a component of
ABCG2 tetramer [plasma membrane] (Homo sapiens)
ABCG2 tetramer [plasma membrane] (Homo sapiens)
as a member of
ABCC1,ABCG2 [plasma membrane] (Homo sapiens)
Other forms of this molecule
HC-ABCG2 [apical plasma membrane]
Inferred To
CG18633 [plasma membrane]
(Drosophila melanogaster)
abcg2 [plasma membrane]
(Xenopus tropicalis)
ABCG2A [plasma membrane]
(Sus scrofa)
ABCG2 [plasma membrane]
(Bos taurus)
Abcg2 [plasma membrane]
(Canis familiaris)
wht-5 [plasma membrane]
(Caenorhabditis elegans)
abcx-1 [plasma membrane]
(Caenorhabditis elegans)
HC-ABCG2 [plasma membrane]
(Dictyostelium discoideum)
HC-ABCG2 [plasma membrane]
(Drosophila melanogaster)
HC-ABCG2 [plasma membrane]
(Mus musculus)
HC-ABCG2 [plasma membrane]
(Plasmodium falciparum)
HC-ABCG2 [plasma membrane]
(Rattus norvegicus)
HC-ABCG2 [plasma membrane]
(Saccharomyces cerevisiae)
HC-ABCG2 [plasma membrane]
(Sus scrofa)
Homologues of HC-ABCG2 [plasma membrane]
(Caenorhabditis elegans)
Homologues of HC-ABCG2 [plasma membrane]
(Dictyostelium discoideum)
Homologues of HC-ABCG2 [plasma membrane]
(Drosophila melanogaster)
Homologues of HC-ABCG2 [plasma membrane]
(Sus scrofa)
Modified Residues
Name
L-cystine (cross-link) at 603
Coordinate
603
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Cross References
RefSeq
XP_011530722.1
,
NP_001244315.1
,
XP_005263412.1
,
NP_004818.2
ZINC - World Drugs
ABCG2_HUMAN
Guide to Pharmacology - Targets
792
OpenTargets
ENSG00000118777
ZINC - FDA approved
ABCG2_HUMAN
ZINC - Substances
ABCG2_HUMAN
ZINC target
Q9UNQ0
ZINC - Biogenic
ABCG2_HUMAN
PRO
Q9UNQ0
PDB
8BI0
,
8P8A
,
6VXH
,
7NFD
,
6VXF
,
7NEZ
,
6FEQ
,
8BHT
,
6ETI
,
7OJ8
,
5NJ3
,
6HIJ
,
8P8J
,
6VXJ
,
6HBU
,
7OJI
,
6HCO
,
6FFC
,
5NJG
,
7OJH
,
6VXI
,
6HZM
,
8P7W
,
7NEQ
ZINC - Investigational
ABCG2_HUMAN
ZINC - Metabolites
ABCG2_HUMAN
HPA
ENSG00000118777-ABCG2
GeneCards
Q9UNQ0
Ensembl
ENSP00000237612
,
ENST00000515655
,
ENST00000650821
,
ENSG00000118777
,
ENSP00000426917
,
ENSP00000498246
,
ENST00000237612
Pharos - Targets
Q9UNQ0
ZINC - Predictions - Purchasable
ABCG2_HUMAN
Orphanet
24321
HMDB Protein
HMDBP02257
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UNQ0 ABCG2
2
HC-ABCG2 [apical plasma membrane]
(R-HSA-9794401)
HC-ABCG2 [plasma membrane]
(R-HSA-917929)
0.791
5
UniProt:P11309-2 PIM1
0.639
5
UniProt:P22413 ENPP1
1
ENPP1 [plasma membrane]
(R-HSA-196973)
0.602
4
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