Reactome | FUT2 transfers Fuc to Type 1 chains to form H antigen-sec

FUT2 transfers Fuc to Type 1 chains to form H antigen-sec

Stable Identifier

R-HSA-9036987

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi lumen, Golgi membrane

ReviewStatus

5/5

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FUT2 transfers Fuc to Type 1 chains to form H antigen-sec

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The H antigen is formed by the addition of a fucose (Fuc) sugar onto one of two precursor oligosaccharide sequences; Type 1 or Type 2 chains. Type 2 chains are found on red blood cells (RBCs), epithelial cells and endothelial cells whereas Type 1 chains are primarily found in bodily secretions. The FUT2 gene (aka Se gene) is expressed in secretory epithelial cells in salivary glands and the gastrointestinal tract and produces galactoside 2-α-L-fucosyltransferase 2 (FUT2 aka α-1,2-fucosyltransferase 2) which mediates the transfer of a Fuc sugar to the galactose (Gal) sugar of the Type 1 chain precursor Gal-β1,3-GlcNAc-β1,3-Gal-R (where R is a glycoprotein) to form the H antigen (Kelly et al. 1995, Koda et al. 1997). This is an essential step for subsequent formation of A and B antigens. Mutations that inactivate the FUT2 gene can result in the 'Bombay phenotype' where no A, B or H antigens are produced in secretions (Koda et al 1997b, Kelly et al. 1994).

Literature References

PubMed ID	Title	Journal	Year
7876235	Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype Kelly, RJ, Lowe, JB, Lennon, GG, Giorgi, D, Rouquier, S	J. Biol. Chem.	1995
9219535	Structure and expression of the gene encoding secretor-type galactoside 2-alpha-L-fucosyltransferase (FUT2) Wang, B, Soejima, M, Koda, Y, Kimura, H	Eur. J. Biochem.	1997
9299444	Missense mutation of FUT1 and deletion of FUT2 are responsible for Indian Bombay phenotype of ABO blood group system Johnson, PH, Soejima, M, Koda, Y, Smart, E, Kimura, H	Biochem. Biophys. Res. Commun.	1997
7912436	Molecular basis for H blood group deficiency in Bombay (Oh) and para-Bombay individuals Larsen, RD, Kelly, RJ, Lowe, JB, Robinson, JS, Bryant, JG, Ernst, LK	Proc. Natl. Acad. Sci. U.S.A.	1994