NTRK3 activates RAS through SHC1

Stable Identifier
R-HSA-9036970
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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NTRK3 activates RAS through SHC1
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Stimulation of NTRK3 (TRKC) by recombinant human NTF3 (NT-3) increases the amount of GTP-bound RAS (Marsh and Palfrey 1996). Activation of RAS targets MAPK3 (ERK1) and MAPK1 (ERK2) was shown to depend on SHC1-mediated recruitment of GRB2 to activated NTRK3 (Gunn-Moore et al. 1997, Yuen and Mobley 1999).
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
NTF3:p-5Y-NTRK3 homodimer:p-Y-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Inferred From
Ntrk3 activates Ras (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2018-01-02)
Reviewed
Tsoulfas, P  (2018-05-09)
Created
Orlic-Milacic, M  (2018-02-15)
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