TYSND1 cleaves HSD17B4

Stable Identifier
R-HSA-9033530
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The trypsin-like serine-type endopeptidase TYSND1 cleaves HSD17B4 (Peroxisomal multifunctional enzyme type 2, MFP-2) between amino acid residues 311 and 312, yielding HSD17B4(1-311) and HSD17B4(312-736) (Okumoto et al. 2011, also inferred from mouse homologs). HSD17B4(1-311) dehydrogenates 3-hydroxyacyl-CoA; HSD17B4(312-736) acts as an enoyl-CoA hydratase (Jiang et al. 1997, reviewed in Huyghe et al. 2006). (In vitro, HSD17B4(312-736) facilitates the transfer of 7-dehydrocholesterol and phosphatidylcholine between membranes.) The uncleaved protein (HSD17B4) also catalyzes these reactions.

Literature References
PubMed ID Title Journal Year
9089413 Structure of D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein

Jiang, LL, Miyazawa, S, Souri, M, Hashimoto, T

J Biochem 1997
22002062 Two proteases, trypsin domain-containing 1 (Tysnd1) and peroxisomal lon protease (PsLon), cooperatively regulate fatty acid β-oxidation in peroxisomal matrix

Okumoto, K, Kametani, Y, Fujiki, Y

J. Biol. Chem. 2011
16766224 Peroxisomal multifunctional protein-2: the enzyme, the patients and the knockout mouse model

Huyghe, S, Mannaerts, GP, Baes, M, Van Veldhoven, PP

Biochim Biophys Acta 2006
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Catalyst Activity
Title
serine-type endopeptidase activity of TYSND1 [peroxisomal matrix]
Physical Entity
Activity
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Created