EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Stable Identifier
R-HSA-9032478
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Phospholipase C gamma (PLCG1 or PLCG2) bound to the phosphorylated cytoplasmic domain of the EPO receptor (EPOR) hydrolyzes 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to yield the second messengers diacylglycerol and 1D-myo-inositol 1,4,5-trisphosphate (Ren et al. 1994, and inferred from mouse). Erythropoietin may also activate the hydrolysis of phosphatidylcholine and phosphatidylethanolamine (inferred from mouse homologs),
Literature References
PubMed ID Title Journal Year
8034732 Erythropoietin induces tyrosine phosphorylation and activation of phospholipase C-gamma 1 in a human erythropoietin-dependent cell line

Ren, HY, Shimizu, R, Miura, Y, Okada, K, Komatsu, N

J. Biol. Chem. 1994
Participants
Participates
Catalyst Activity

phosphatidylinositol phospholipase C activity of EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-PLCG1,2 [plasma membrane]

Inferred From
Authored
Reviewed
Created
Cite Us!