NGF-stimulated transcription

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R-HSA-9031628
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Pathway
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Homo sapiens
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NGF stimulation induces expression of a wide array of transcriptional targets. In rat PC12 cells, a common model for NGF signaling, stimulation with NGF causes cells to exit the cell cycle and undergo a differentiation program leading to neurite outgrowth. This program is driven by the expression of immediate early genes (IEGs), which frequently encode transcription factors regulating the activity of NGF-specific delayed response genes (reviewed in Sheng and Greenberg, 1990; Flavell and Grennberg, 2008; Santiago and Bashaw, 2014).

Literature References
PubMed ID Title Journal Year
25468936 Transcription factors and effectors that regulate neuronal morphology

Santiago, C, Bashaw, GJ

Development 2014
18558867 Signaling mechanisms linking neuronal activity to gene expression and plasticity of the nervous system

Flavell, SW, Greenberg, ME

Annu. Rev. Neurosci. 2008
2181374 Strong association between c-myb and oestrogen-receptor expression in human breast cancer

Guérin, M, Sheng, ZM, Andrieu, N, Riou, G

Oncogene 1990
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