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NR1H3, NRIP1 bind the PCK1 gene
Stable Identifier
R-HSA-9028524
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
NR1H2 and NR1H3-mediated signaling (Homo sapiens)
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis (Homo sapiens)
NR1H3, NRIP1 bind the PCK1 gene (Homo sapiens)
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Activation by synthetic ligands of liver X receptor (LXR) α (NR1H3) led to the suppression of gluconeogenesis in mouse hepatocytes by down-regulation of phosphoenolpyruvate carboxykinase (PCK1 or PEPCK) gene (Laffitte BA et al. 2003; Herzog B et al. 2007). Notably, both NR1H3 and NR1H2 have been shown to co-localize and interact with receptor-interacting protein 1 (NRIP1 or RIP140) (Jakobsson T et al. 2007; Herzog B et al. 2007). Indeed, depending on the gene, RIP140 can function both as a co-activator and co-repressor of NR1H2 or NR1H3. In the liver for instance, NRIP1 may activate NR1H3 (LXRα)-mediated transcription from lipogenic genes such as FASN and repress transcription of PCK1 gene to regulate metabolic pathways (Herzog B et al. 2007).
Literature References
PubMed ID
Title
Journal
Year
17684114
The nuclear receptor cofactor, receptor-interacting protein 140, is required for the regulation of hepatic lipid and glucose metabolism by liver X receptor
Herzog, B
,
Parker, MG
,
Hallberg, M
,
Woods, A
,
White, R
,
Seth, A
Mol. Endocrinol.
2007
Participants
Input
NR1H3, NR1H2 ligands [nucleoplasm]
NR1H3:RXR [nucleoplasm]
(Homo sapiens)
NRIP1 [nucleoplasm]
(Homo sapiens)
PCK1 gene [nucleoplasm]
(Homo sapiens)
Output
NRIP1:NR1H3:RXR:NR1H3 ligand:PCK1 gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis (Homo sapiens)
Authored
Shamovsky, V (2018-01-19)
Reviewed
D'Eustachio, P (2018-12-29)
Repa, JJ (2019-08-09)
Cummins, CL (2019-08-09)
Created
Shamovsky, V (2017-11-09)
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