Reactome | Biosynthesis of DHA-derived sulfido conjugates

Biosynthesis of DHA-derived sulfido conjugates

Stable Identifier

R-HSA-9026395

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Biosynthesis of DHA-derived sulfido conjugates

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The polyunsaturated fatty acid (PUFA) ω-3 docosahexaenoic acid (DHA) is a precursor for the production of novel sulfido-peptide conjugated mediators with structural similarity to the cysteinyl-leukotrienes and with novel biological properties. They are produced from specialised proresolving mediators (SPMs) in human macrophages and are termed protectin conjugates in tissue regeneration (PCTR), resolvin conjugates in tissue regeneration (RCTR), and maresin conjugates in tissue regeneration (MCTR) because they regulate mechanisms in inflammation resolution as well as tissue regeneration (Dalli et al. 2014, 2015, 2016, Serhan et al. 2017). Their biosynthesis is descibed in this section.

Literature References

PubMed ID	Title	Journal	Year
27791009	Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages Riley, IR, Serhan, CN, Rodriguez, AR, Petasis, NA, Chiang, N, Spur, BW, Vlasakov, I, Dalli, J	Proc. Natl. Acad. Sci. U.S.A.	2016
25324525	Identification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection Serhan, CN, Chiang, N, Dalli, J	Proc. Natl. Acad. Sci. U.S.A.	2014
25713027	Novel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathways Norris, PC, Serhan, CN, Colas, RA, Ramon, S, Dalli, J	FASEB J.	2015
28802833	New pro-resolving n-3 mediators bridge resolution of infectious inflammation to tissue regeneration Serhan, CN, Chiang, N, Dalli, J	Mol. Aspects Med.	2017