PBX1 gene expression is stimulated by NOTCH3

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R-HSA-9021412
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Reaction [omitted]
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Homo sapiens
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PBX1 gene transcription is directly stimulated by the NOTCH3 coactivator complex (Park et al. 2008). NOTCH3 gene is amplified in high-grade ovarian serous carcinoma and NOTCH3 overexpression contributes to cancer cell growth (Park et al. 2006). Overexpression of NOTCH3 in high-grade ovarian serous carcinoma correlates with overexpression of PBX1 (Park et al. 2006, Park et al. 2008). PBX1 gene encodes a homeodomain transcription factor PBX1 which is a B cell leukemia (B-ALL) oncogene (Nourse et al. 1990, Kamps et al. 1991) and is also overexpressed in melanoma (Shiraishi et al. 2007).

Literature References
PubMed ID Title Journal Year
18974129 Identification of Pbx1, a potential oncogene, as a Notch3 target gene in ovarian cancer

Park, JT, Shih, IeM, Wang, TL

Cancer Res. 2008
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