PBX1 gene expression is stimulated by NOTCH3

Stable Identifier
R-HSA-9021412
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PBX1 gene expression is stimulated by NOTCH3
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PBX1 gene transcription is directly stimulated by the NOTCH3 coactivator complex (Park et al. 2008). NOTCH3 gene is amplified in high-grade ovarian serous carcinoma and NOTCH3 overexpression contributes to cancer cell growth (Park et al. 2006). Overexpression of NOTCH3 in high-grade ovarian serous carcinoma correlates with overexpression of PBX1 (Park et al. 2006, Park et al. 2008). PBX1 gene encodes a homeodomain transcription factor PBX1 which is a B cell leukemia (B-ALL) oncogene (Nourse et al. 1990, Kamps et al. 1991) and is also overexpressed in melanoma (Shiraishi et al. 2007).
Literature References
PubMed ID Title Journal Year
18974129 Identification of Pbx1, a potential oncogene, as a Notch3 target gene in ovarian cancer

Park, JT, Wang, TL, Shih, IeM

Cancer Res. 2008
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Output
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as an event of
Event Information
Go Biological Process
positive regulation of transcription of Notch receptor target (0007221)
This event is regulated
Positively by
Regulator
NOTCH3 coactivator complex:PBX1 gene [nucleoplasm] (Homo sapiens)
Active Unit
NOTCH3 coactivator complex [nucleoplasm]
Authored
Orlic-Milacic, M  (2017-09-20)
Reviewed
Haw, R  (2017-10-30)
Created
Orlic-Milacic, M  (2017-09-18)
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