NOTCH3 coactivator complex binds HEYL gene promoter

Stable Identifier
R-HSA-9017398
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NOTCH3 coactivator complex binds HEYL gene promoter
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Based on the findings that the NOTCH3 coactivator complex component RBPJ (CSL) binds to RBPJ response elements in the promoter of the HEYL gene (Geimer Le Lay et al. 2014) and that HEYL gene expression is stimulated by NOTCH3 (Maier and Gessler 2000) and overlaps with NOTCH3 expression in vascular smooth muscle cells and the thymus (Leimeister et al. 2000), it can be concluded that the NOTCH3 coactivator complex binds the promoter of the HEYL gene.
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Output
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Event Information
Go Biological Process
positive regulation of transcription of Notch receptor target (0007221)
Inferred From
Notch3 coactivator complex binds the Heyl gene promoter (Mus musculus)
Authored
Orlic-Milacic, M  (2017-09-20)
Reviewed
Haw, R  (2017-10-30)
Created
Orlic-Milacic, M  (2017-08-21)
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