RUNX2-P2 binds RUNX2 gene promoter

Stable Identifier
R-HSA-9016526
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
RUNX2-P2 binds RUNX2 gene promoter
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Based on studies in mice, RUNX2-P2 (RUNX2 variant expressed from the proximal promoter) binds to RUNX2 response elements in the proximal P2 promoter of the RUNX2 gene (Ducy et al. 1999). It is assumed that RUNX2 is associated with at least CBFB and the RUNX2 promoter, although this has not been examined.
Literature References
PubMed ID Title Journal Year
10215629 A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development

Geoffroy, V, Priemel, M, Karsenty, G, Starbuck, M, Ducy, P, Pinero, G, Amling, M, Shen, J

Genes Dev. 1999
Participants
Input
Output
Participates
as an event of
Inferred From
Runx2-P2 binds to Runx2 gene promoter (Mus musculus)
Authored
Orlic-Milacic, M  (2017-08-14)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2017-08-14)
Cite Us!