TXLNA (IL14) binds syntaxin3

Stable Identifier
R-HSA-9014052
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Interleukin-14, renamed alpha-taxilin (TXLNA) was originally described as High molecular weight B-cell growth factor (Ambrus et al. 1994). TXLNA binds several forms of syntaxin (Nogami et al. 2003), but not when they are complexed with SNAP25, VAMP2 or STXBP1, suggesting that TXLNA interacts with syntaxins outside the SNARE complex. This observation and a predicted role in intracellular vesicle trafficking led to renaming of the gene. Txlna transgenic mice show a phenotype similar to systemic lupus erythematosus and Sjogren's syndrome (Shen et al. 2006).
Literature References
PubMed ID Title Journal Year
12558796 Taxilin; a novel syntaxin-binding protein that is involved in Ca2+-dependent exocytosis in neuroendocrine cells

Shimizu, H, Fukushima, H, Nakano, M, Shirataki, H, Terano, A, Satoh, S, Maruyama, A, Nogami, S

Genes Cells 2003
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