HES1 gene expression is stimulated by NOTCH3 and STAT1

Stable Identifier
R-HSA-9013567
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Based on studies in a mouse system, HES1 gene expression is directly stimulated by the NOTCH3 coactivator complex (Lin et al. 2002, Shimizu et al. 2002). Activated STAT1 directly enhances HES1 transcription induced by NICD3 (Boelens et al. 2014).
Literature References
PubMed ID Title Journal Year
11866432 Functional diversity among Notch1, Notch2, and Notch3 receptors

Shimizu, K, Hirai, H, Kumano, K, Hamada, Y, Saito, T, Chiba, S

Biochem Biophys Res Commun 2002
12386158 Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling

Oyama, T, Nagase, T, Lin, SE, Kitagawa, M, Harigaya, K

J. Biol. Chem. 2002
25417103 Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways

Wiemann, BZ, Qiu, Y, Nabet, BY, Ishwaran, H, Wu, TJ, Slingerland, J, Twyman-Saint Victor, C, Xu, B, Minn, AJ, Yoon, T, Ter Brugge, PJ, Jonkers, J, Boelens, MC, Azzam, DJ

Cell 2014
Participants
Participates
Event Information
This event is regulated
Inferred From
Authored
Reviewed
Created
Cite Us!