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KPNA2 translation is negatively regulated by miR-26A and B
Stable Identifier
R-HSA-9012196
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Estrogen-dependent gene expression (Homo sapiens)
KPNA2 translation is negatively regulated by miR-26A and B (Homo sapiens)
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Translation of KPNA2 is negatively regulated by binding of mIR-26A and mIR-26B to the 3' UTR.
Literature References
PubMed ID
Title
Journal
Year
24735615
Identification of miR-26 as a key mediator of estrogen stimulated cell proliferation by targeting CHD1, GREB1 and KPNA2
Li, G
,
Kong, X
,
Tan, S
,
Zhu, T
,
Ding, K
,
Li, R
,
Lobie, PE
,
Qian, P
,
Zhang, W
Breast Cancer Res.
2014
Participants
Input
KPNA2 mRNA [cytosol]
(Homo sapiens)
Output
KPNA2 [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Estrogen-dependent gene expression (Homo sapiens)
This event is regulated
Negatively by
Regulator
KPNA2 mRNA:mIR-26 RISC [cytosol]
(Homo sapiens)
Active Unit
miR-26 RISC [cytosol]
Authored
Rothfels, K (2017-09-29)
Reviewed
Magnani, L (2018-02-23)
Created
Rothfels, K (2017-07-11)
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