GREB1 translation is negatively regulated by miR-26A and B

Stable Identifier
R-HSA-9011961
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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GREB1 translation is negatively regulated by miR-26A and B
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Translation of GREB1 mRNA is negatively regulated by direct binding of mIR-26A and mIR-26B to the 3' UTR. mIR-26 expression is itself negatively regulated in response to estrogen in a manner that depends on estrogen-stimulated MYC gene expression (Tan et al, 2014).
Literature References
PubMed ID Title Journal Year
24735615 Identification of miR-26 as a key mediator of estrogen stimulated cell proliferation by targeting CHD1, GREB1 and KPNA2

Li, G, Kong, X, Tan, S, Zhu, T, Ding, K, Li, R, Lobie, PE, Qian, P, Zhang, W

Breast Cancer Res. 2014
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
GREB1 mRNA:miR-26 RISC [cytosol] (Homo sapiens)
Active Unit
miR-26 RISC [cytosol]
Authored
Rothfels, K  (2017-09-29)
Reviewed
Magnani, L  (2018-02-23)
Created
Rothfels, K  (2017-07-07)
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