APP translocates from plasma membrane to endosome lumen

Stable Identifier
R-HSA-9010091
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
endosome lumen, plasma membrane
ReviewStatus
5/5
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APP translocates from plasma membrane to endosome lumen
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
APP that does not get processed by alpha-secretase in the non-amyloidogenic pathway is internalised to endosomes for further processing (Baranello et al. 2015).
Literature References
PubMed ID Title Journal Year
25523424 Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease

Padmaraju, V, Lahiri, DK, Chopra, N, Sambamurti, K, Baranello, RJ, Pappolla, MA, Greig, NH, Bharani, KL

Curr Alzheimer Res 2015
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Output
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as an event of
Authored
Jassal, B  (2017-06-26)
Reviewed
Meras-Rios, A  (2018-08-10)
Created
Jassal, B  (2017-06-26)
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