STUB1 polyubiquitinates RUNX2

Stable Identifier
R-HSA-9009308
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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STUB1 (CHIP), an E3 ubiquitin ligase, promotes polyubiquitination of RUNX2, targeting it for proteasome-mediated degradation (Li et al. 2008).

Literature References
PubMed ID Title Journal Year
18541707 CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation

Li, X, Huang, M, Zheng, H, Wang, Y, Ren, F, Shang, Y, Zhai, Y, Irwin, DM, Shi, Y, Chen, D, Chang, Z

J. Cell Biol. 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of RUNX2:STUB1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created