STAT3 phosphorylation

Stable Identifier
R-HSA-9009072
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
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Signal transducer and activator of transcription 3 (STAT3) acts downstream of various cellular receptors and is primarily involved in gene transcription. STAT3 is activated by serine/threonine kinases (Rebe et al. 2013). The IL-37:IL-18R1:SIGIRR complex can facilitate the phosphorylation and activation of STAT3 (Nold Petry et al. 2015). However, the precise mechanism is unclear. Hence, this event is represented as a black box.

Literature References
PubMed ID Title Journal Year
25729923 IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction

Nold-Petry, CA, Lo, CY, Rudloff, I, Elgass, KD, Li, S, Gantier, MP, Lotz-Havla, AS, Gersting, SW, Cho, SX, Lao, JC, Ellisdon, AM, Rotter, B, Azam, T, Mangan, NE, Rossello, FJ, Whisstock, JC, Bufler, P, Garlanda, C, Mantovani, A, Dinarello, CA, Nold, MF

Nat. Immunol. 2015
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