RUNX2 binds BAX gene promoter

Stable Identifier
R-HSA-9008832
Type
Reaction [binding]
Species
Homo sapiens
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RUNX2, presumably in complex with CBFB, binds the promoter of the BAX gene (Eliseev et al. 2008, Goloudina, Tanoue et al. 2012, Goloudina, Mazur et al. 2012). Signaling downstream of BMP2 promotes RUNX2-mediated activation of the BAX gene transcription (Eliseev et al. 2008). Dephosphorylation of RUNX2 serine residue S432 by the PPM1D (WIP1) serine/threonine phosphatase promotes association of RUNX2 with the BAX promoter (Goloudina, Tanoue et al. 2012, Goloudina, Mazur et al. 2012).

Literature References
PubMed ID Title Journal Year
22065775 Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agents

Goloudina, AR, Tanoue, K, Hammann, A, Fourmaux, E, le Guezennec, X, Bulavin, DV, Mazur, SJ, Appella, E, Garrido, C, Demidov, ON

Proc. Natl. Acad. Sci. U.S.A. 2012
18223689 Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis

Eliseev, RA, Dong, YF, Sampson, E, Zuscik, MJ, Schwarz, EM, O'Keefe, RJ, Rosier, RN, Drissi, MH

Oncogene 2008
22544321 Wip1 sensitizes p53-negative tumors to apoptosis by regulating the Bax/Bcl-xL ratio

Goloudina, AR, Mazur, SJ, Appella, E, Garrido, C, Demidov, ON

Cell Cycle 2012
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