CDKN1A gene expression is inhibited by RUNX2

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R-HSA-9008456
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Reaction [omitted]
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Homo sapiens
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Binding of RUNX2 to the CDKN1A gene promoter inhibits CDKN1A transcription, thus preventing CDKN1A-induced cell cycle arrest. Phosphorylation of RUNX2 by CDK4 in response to high glucose enhances RUNX2-mediated repression of the CDKN1A gene in endothelial cells (Pierce et al. 2012). HDAC6, which forms a complex with RUNX2, may contribute to RUNX2-mediated repression of CDKN1A in developing osteoblasts (Westendorf et al. 2002). In mice, Runx2-mediated repression of Cdkn1a may contribute to the development of acute myeloid leukemia (AML) (Kuo et al. 2009).

Literature References
PubMed ID Title Journal Year
21913213 Glucose-activated RUNX2 phosphorylation promotes endothelial cell proliferation and an angiogenic phenotype

Pierce, AD, Anglin, IE, Vitolo, MI, Mochin, MT, Underwood, KF, Goldblum, SE, Kommineni, S, Passaniti, A

J. Cell. Biochem. 2012
12391164 Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter

Westendorf, JJ, Zaidi, SK, Cascino, JE, Kahler, R, van Wijnen, AJ, Lian, JB, Yoshida, M, Stein, GS, Li, X

Mol. Cell. Biol. 2002
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