RUNX2 binds ZNF521 and HDAC3

Stable Identifier
R-HSA-9008137
Type
Reaction [binding]
Species
Homo sapiens
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Based on studies in mice, RUNX2 forms a complex with ZNF521 (ZNP521) and a histone deacetylase HDAC3. Binding to ZNF521 does not inhibit RUNX2 binding to target genes, such as the BGLAP (Osteocalcin) gene promoter, but inhibits RUNX2-mediated activation of these genes. HDAC3 is needed for ZNF521 to inhibit RUNX2-mediated transcription from the BGLAP promoter. Action of ZNF521 antagonizes RUNX2 during mesenchymal commitment to the osteoblast lineage and during osteoblast maturation (Hesse et al. 2010).

Literature References
PubMed ID Title Journal Year
21173110 Zfp521 controls bone mass by HDAC3-dependent attenuation of Runx2 activity

Hesse, E, Saito, H, Kiviranta, R, Correa, D, Yamana, K, Neff, L, Toben, D, Duda, G, Atfi, A, Geoffroy, V, Horne, WC, Baron, R

J. Cell Biol. 2010
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