UXT gene expression is repressed by the PRC1L4 complex

Stable Identifier
R-HSA-9007465
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Binding of the PRC1L4 complex, composed of E2F6, CBX3 (HP1gamma), PCGF6 (MBLR), L3MBTL2 and RING1 or RNF2, to the UXT gene promoter represses UXT transcription. This is concluded based on experimental evidence of direct association of the PRC1L4 complex with the UXT gene promoter and increased UXT expression upon E2F6 or L3MBTL2 knockdown (Trojer et al. 2011). E2F6 was also reported as a repressor of the UXT gene transcription by Oberley et al. 2013.
Literature References
PubMed ID Title Journal Year
12909625 E2F6 negatively regulates BRCA1 in human cancer cells without methylation of histone H3 on lysine 9

Inman, DR, Oberley, MJ, Farnham, PJ

J. Biol. Chem. 2003
21596310 L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure

Trojer, P, Gao, Z, Reinberg, D, Losson, R, Farnham, PJ, Xu, X, Li, Y, Li, G, Cao, AR, Zhang, J, Tempst, P, Erdjument-Bromage, H

Mol. Cell 2011
Participants
Participates
This event is regulated
Authored
Reviewed
Created
Cite Us!