IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5

Stable Identifier
R-HSA-8987266
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
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IFNL1 can induce phosphorylation of Signal transducer and activator of transcription 1 alpha/beta (STAT1), Signal transducer and activator of transcription 2 (STAT2) , Signal transducer and activator of transcription 3 (STAT3) , Signal transducer and activator of transcription 4 (STAT4) ,Signal transducer and activator of transcription 5 (STAT5) (Dumoutier et al. 2004, Novak et al. 2008), Signal transducer and activator of transcription 2 (STAT2)(Dickensheets et al. 2013), Signal transducer and activator of transcription 4 (STAT4) and Signal transducer and activator of transcription 5 (STAT5) (Dumoutier et al. 2004). This is a black-box event because direct evidence for STAT4 and 5-binding and activation is lacking. STAT binding is inferred from subsequent phosphorylation in response to IFNL1 (Jordan et al. 2007).

Literature References
PubMed ID Title Journal Year
18830264 A role for IFN-lambda1 in multiple myeloma B cell growth

Novak, AJ, Grote, DM, Ziesmer, SC, Rajkumar, V, Doyle, SE, Ansell, SM

Leukemia 2008
Participants
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Orthologous Events
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Created