Reactome | IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3

IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3

Stable Identifier

R-HSA-8987255

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

Synonyms

STAT1,STAT3 are phosphorylated by IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1, STAT1,STAT3 are phosphorylated by IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1, STAT1,STAT3 are phosphorylated by IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1

ReviewStatus

5/5

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IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3

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Signal transducer and activator of transcription 1 alpha/beta (STAT1) or Signal transducer and activator of transcription 3 (STAT3) are believed to be phosphorylated by the Interleukin 26 (IL26) receptor complex,which consists of IL26, Interleukin-10 receptor subunit beta (IL10RB), phosphorylated Non-receptor tyrosine-protein kinase TYK2 (TYK2), Interleukin-20 receptor subunit alpha (IL20RA), phosphorylated Tyrosine-protein kinase JAK1 (JAK1) (Sheikh et al. 2004), STAT1 and STAT3.
This is a black box event since there is no direct evidence that STAT1 or STAT3 bind the receptor complex before being phosphorylated, but this can be inferred from the signaling mechanism of other related interleukin receptors such as IL10 (Weber-Nordt et al. 1996, Braum et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
14764663	Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2 Baurin, VV, Lewis-Antes, A, Shah, NK, Dumoutier, L, Zdanov, A, Anantha, S, Smirnov, SV, Sheikh, F, Renauld, JC, Dickensheets, H, Donnelly, RP, Kotenko, SV	J. Immunol.	2004