p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1

Stable Identifier
R-HSA-8987230
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
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Phosphorylated Signal transducer and activator of transcription 3 (STAT3) and Signal transducer and activator of transcription 1 alpha/beta (STAT1) are believed to dissociate from the Interleukin-26 (IL26) receptor complex. This is a black-box event because dissociation is inferred from other interleukin signaling cascades, e.g. Interleukin-10 (Niemand et al. 2003, Braum et al. 2013, Xiong et al. 2014, Sheikh et al. 2006, You et al. 2013) where dissociation occurs before dimerization and translocation to the nucleus.

Literature References
PubMed ID Title Journal Year
23704922 IL-26 promotes the proliferation and survival of human gastric cancer cells by regulating the balance of STAT1 and STAT3 activation

You, W, Tang, Q, Zhang, C, Wu, J, Gu, C, Wu, Z, Li, X

PLoS ONE 2013
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