p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1

Stable Identifier
R-HSA-8987230
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Phosphorylated Signal transducer and activator of transcription 3 (STAT3) and Signal transducer and activator of transcription 1 alpha/beta (STAT1) are believed to dissociate from the Interleukin-26 (IL26) receptor complex. This is a black-box event because dissociation is inferred from other interleukin signaling cascades, e.g. Interleukin-10 (Niemand et al. 2003, Braum et al. 2013, Xiong et al. 2014, Sheikh et al. 2006) where dissociation occurs before dimerization and translocation to the nucleus.
Literature References
PubMed ID Title Journal Year
14764663 Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2

Baurin, VV, Lewis-Antes, A, Shah, NK, Dumoutier, L, Zdanov, A, Anantha, S, Smirnov, SV, Sheikh, F, Renauld, JC, Dickensheets, H, Donnelly, RP, Kotenko, SV

J. Immunol. 2004
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!