IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3

Stable Identifier
R-HSA-8987179
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Synonyms
JAK2, JAK3 are phosphorylated after IL20:IL20RA:JAK1:IL20RB:JAK2:JAK3 interaction, JAK2, JAK3 are phosphorylated after IL20 IL20 receptor, JAK2, JAK3 are phsophorylated after IL20 stimulus
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Tyrosine-protein kinase JAK2 (JAK2) or Tyrosine-protein kinase JAK3 (JAK3) are phosphorylated after the binding of Interleukin-20 (IL20) to a heterodimeric receptor complex formed by Interleukin-20 receptor subunit alpha (IL20RA) associated with Tyrosine-protein kinase JAK1 (JAK1) and Interleukin-20 receptor subunit beta (IL20RB).
JAK2 is phosphorylated at Tyr-1007/1008 (Tritsaris et al. 2007). JAK3 is also phosphorylated (Lee et al. 2012).
This is a black box event because it is unclear whether JAK2 and JAK3 are phosphorylated simultaneously or sequentially during IL20 stimulation.

Literature References
PubMed ID Title Journal Year
22962576 Identification of pro-inflammatory cytokines associated with muscle invasive bladder cancer; the roles of IL-5, IL-20, and IL-28A

Lee, SJ, Lee, EJ, Kim, SK, Jeong, P, Cho, YH, Yun, SJ, Kim, S, Kim, GY, Choi, YH, Cha, EJ, Kim, WJ, Moon, SK

PLoS ONE 2012
17878297 IL-20 is an arteriogenic cytokine that remodels collateral networks and improves functions of ischemic hind limbs

Tritsaris, K, Myren, M, Ditlev, SB, H├╝bschmann, MV, van der Blom, I, Hansen, AJ, Olsen, UB, Cao, R, Zhang, J, Jia, T, Wahlberg, E, Dissing, S, Cao, Y

Proc. Natl. Acad. Sci. U.S.A. 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
transmembrane receptor protein tyrosine kinase activity of IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created