IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3

Stable Identifier
R-HSA-8987150
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Synonyms
STAT3 is phosphorylated by IL24:p-IL20RA:p-JAK1:IL20RB:STAT3 activated receptor complex, STAT3 is phosphorylated in IL24:IL24 receptor complex
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Signal transducer and activator of transcription 1 alpha/beta (STAT1) and Signal transducer and activator of transcription 3 (STAT3) are believed to be phosphorylated after binding the Interleukin-24 (IL24) receptor complex (Parrish Novak et al. 1998, Andoh et al. 2009, Wang et al. 2002). This complex consists of IL24 ligand, phosphorylated Interleukin-20 receptor subunit alpha (IL20RA), phosphorylated Tyrosine-protein kinase JAK1 (JAK1), Interleukin-20 receptor subunit beta (IL20RB) and STAT1 or STAT3 .
This is a black box event because STAT binding is inferred to precede STAT phosphorylation.

Literature References
PubMed ID Title Journal Year
18941194 IL-24 induces apoptosis of chronic lymphocytic leukemia B cells engaged into the cell cycle through dephosphorylation of STAT3 and stabilization of p53 expression

Sainz-Perez, A, Gary-Gouy, H, Gaudin, F, Maarof, G, Marfaing-Koka, A, de Revel, T, Dalloul, A

J. Immunol. 2008
19535621 Expression of IL-24, an activator of the JAK1/STAT3/SOCS3 cascade, is enhanced in inflammatory bowel disease

Andoh, A, Shioya, M, Nishida, A, Bamba, S, Tsujikawa, T, Kim-Mitsuyama, S, Fujiyama, Y

J. Immunol. 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
transmembrane receptor protein tyrosine kinase activity of IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created