IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3

Stable Identifier
R-HSA-8987141
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Signal transducer and activator of transcription 5A and 5B (STAT5A, STAT5B) is phosphorylated after binding the Interleukin-20 (IL20) receptor complex, which consist of IL20, Interleukin-20 receptor subunit alpha (IL20RA), phosphorylated Tyrosine-protein kinase JAK1 (JAK1), Interleukin-20 receptor subunit beta (IL20RB), phosphorylated Tyrosine-protein kinase JAK2 (JAK2), Tyrosine-protein kinase JAK3 (JAK3) and STAT5. After IL20 stimulation STAT5 is phosphorylated at Tyr-694 (Tritsaris et al. 2007). It is not clear which kinase subunit of the receptor complex is responsible for STAT5 phosphorylation.

Literature References
PubMed ID Title Journal Year
17878297 IL-20 is an arteriogenic cytokine that remodels collateral networks and improves functions of ischemic hind limbs

Tritsaris, K, Myren, M, Ditlev, SB, H├╝bschmann, MV, van der Blom, I, Hansen, AJ, Olsen, UB, Cao, R, Zhang, J, Jia, T, Wahlberg, E, Dissing, S, Cao, Y

Proc. Natl. Acad. Sci. U.S.A. 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
transmembrane receptor protein tyrosine kinase activity of IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3:STAT3 [plasma membrane]
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Activity
Orthologous Events
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