IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3

Stable Identifier
R-HSA-8987104
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Synonyms
STAT5 binds to IL20:IL20RA:JAK1:IL20RB:p-JAK2,p-JAK3 activated receptor complex, STAT5 binds to Activated IL20 IL20 Receptor JAK2 complex
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Signal transducer and activator of transcription 3 (STAT3)and STAT5 are believed to bind the receptor complex following the phosphorylation of JAK2 and JAK3 within the IL20:IL20RA receptor complex, because Interleukin-20 (IL20) stimulation leads to STAT3 nuclear translocation (Blumberg et al. 2001, Parrish-Novak et a. 2002)). Phosphorylation of STAT5 at Tyr-694 has been observed in response to IL20 but it is not clear which IL20 receptor was involved (Tritsaris et al. 2007). This is a black box event because there is no direct evidence of STAT3 or STAT5 binding, which is inferred to be a prerequisite for STAT phosphorylation in response to IL20.

Literature References
PubMed ID Title Journal Year
12351624 Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions

Parrish-Novak, J, Xu, W, Brender, T, Yao, L, Jones, C, West, J, Brandt, C, Jelinek, L, Madden, K, McKernan, PA, Foster, DC, Jaspers, S, Chandrasekher, YA

J Biol Chem 2002
11163236 Interleukin 20: discovery, receptor identification, and role in epidermal function

Blumberg, H, Conklin, D, Xu, WF, Grossmann, A, Brender, T, Carollo, S, Eagan, M, Foster, D, Haldeman, BA, Hammond, A, Haugen, H, Jelinek, L, Kelly, JD, Madden, K, Maurer, MF, Parrish-Novak, J, Prunkard, D, Sexson, S, Sprecher, C, Waggie, K, West, J, Whitmore, TE, Yao, L, Kuechle, MK, Dale, BA, Chandrasekher, YA

Cell 2001
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created