IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3

Stable Identifier
R-HSA-8987070
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
STAT3 is phosphorylated by IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:STAT3 activated receptor complex, STAT3 is phosphorylated by the IL22 activated receptor complex
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Signal transducer and activator of transcription 3 (STAT3) is phosphorylated by the Interleukin-22 (IL22) receptor complex (Lejeune et al. 2002, Dumoutier et al. 2009, Lindemanns et al. 2015), which consists of IL22, phosphorylated Interleukin-22 receptor subunit alpha-1 (IL22RA1), phosphorylated Tyrosine-protein kinase JAK1 (JAK1), Interleukin-10 receptor subunit beta (IL10RB), phosphorylated Non-receptor tyrosine-protein kinase TYK2 (TYK2) and STAT3 (Meng et al. 2010, Sestito et al. 2011).

Literature References
PubMed ID Title Journal Year
21098725 STAT3-dependent effects of IL-22 in human keratinocytes are counterregulated by sirtuin 1 through a direct inhibition of STAT3 acetylation

Sestito, R, Madonna, S, Scarponi, C, Cianfarani, F, Failla, CM, Cavani, A, Girolomoni, G, Albanesi, C

FASEB J. 2011
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
transmembrane receptor protein tyrosine kinase activity of IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:STAT3 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created